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Ion-exchange HPLC in drug assay in biological fluids IV. Nadolol diastereomers: demonstration of pharmacokinetic and binding equivalence
Summary
Type:
HPLC
Application #:
104110
Catalog#:
720097.46 - MN HPLC Column, Nucleosil SA, 100A, 5um, 4.6x250mm
Detection:
fluorescence, excitation 214nm, emission filter 230 - 400nm
Conditions:
eluent: acetonitrile - water (15:85) + 0.2% (v/v) orthophosphoric acid (1.71g/cm3), adjusted to pH 4.1 with diethylamine
flow rate 1ml/min
Authors:
Piotrovskii VK
Source:
J Chromatogr 309 (1984) 421 - 425
Details
Legend: Fig. 1. A) Chromatogram of nadolol and procainamide standards, 1. racemate B, 2. racemate A, 3. procainamide, B) chromatogram of an extract of blank serum spiked with 500ng/ml nadolol and procainami
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